The function of GLI2 (GLI family zinc finger 2, Ensembl gene identifier ENSG00000074047) is as follows. Transcription factor that acts as a key effector of the smoothened signaling pathway, and which plays a role in skeleton development (PubMed:15994174, PubMed:18455992, PubMed:19878745, PubMed:20154143, PubMed:20685856, PubMed:24311597, PubMed:26565916, PubMed:9557682). Specifically binds to the minimal GLI-consensus sequence 5'-GACCACCCA-3' to activate or repress the expression of target genes (By similarity). Functions both as a transcriptional activator and repressor: the full-length GLI2 form (Transcription activator GLI2) acts as a transcription activator following smoothened activation, while the Transcription repressor GLI2R, which is generated in absence of smoothened, acts as a transcription repressor (By similarity). The transcriptional activator form constitutes the major form of GLI2 (By similarity). {ECO:0000250|UniProtKB:Q0VGT2, ECO:0000269|PubMed:15994174, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:20154143, ECO:0000269|PubMed:20685856, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:9557682}. [Transcription activator GLI2]: Transcription factor, which activates expression of target genes in response to smoothened (SMO) activation (PubMed:18455992, PubMed:19878745, PubMed:24311597, PubMed:26565916, PubMed:9557682). Constitutes a major form of GLI2, while the transcription repressor form (GLI2R) plays a minor role (By similarity). {ECO:0000250|UniProtKB:Q0VGT2, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:26565916, ECO:0000269|PubMed:9557682}. [Transcription repressor GLI2R]: Transcription repressor, which inhibits expression of target genes in the absence of smoothened (SMO) signaling (By similarity). Generated by proteolytic processing of the full-length GLI2 form in the absence of hedgehog (DHH, IHH or SHH), when SMO transducer is inhibited (By similarity). Constitutes a minor form of GLI2, while the transcription activator GLI2 form plays a major role in smoothened signaling (By similarity). . [Isoform 1]: Involved in the smoothened (SHH) signaling pathway. . [Isoform 2]: Involved in the smoothened (SHH) signaling pathway. . [Isoform 3]: Involved in the smoothened (SHH) signaling pathway. . [Isoform 4]: Involved in the smoothened (SHH) signaling pathway. . [Isoform 5]: Acts as a transcriptional repressor. . [Isoform 1]: (Microbial infection) Acts as a transcriptional activator in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). . [Isoform 2]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). . [Isoform 3]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). . [Isoform 4]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682). .