The function of ENSG00000075073 (TACR2, tachykinin receptor 2) is as follows. This is a receptor for the tachykinin neuropeptide substance K (neurokinin A) (PubMed:1659297, PubMed:1848773). Is also able to bind and respond to tachynins substance P and neurokinin B/neuromedin-K (By similarity). The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P (By similarity). Substance K binding to its receptor triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol hydrolysis by phospholipase C (PubMed:7957923, PubMed:35882833). Substance K binding also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP) (By similarity). {ECO:0000250|UniProtKB:P30549, ECO:0000269|PubMed:1659297, ECO:0000269|PubMed:1848773, ECO:0000269|PubMed:35882833, ECO:0000269|PubMed:7957923}.