Accessory protein that regulates signaling by multiple TLRs, acting as a broad-spanning regulator of the innate immune response. In macrophages, binds LPS and promotes proper docking of LPS in lipid raft membrane. May be required for lipid raft maintenance. . This is the function of Ensembl gene identifier ENSG00000077454 (LRCH4, leucine rich repeats and calponin homology domain containing 4).