The function of UBE2D4 (ubiquitin conjugating enzyme E2 D4, Ensembl gene identifier ENSG00000078967) is as follows. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11' and 'Lys-48'-linked polyubiquitination. .