Regulates cellular transport and efflux of cholesterol (PubMed:26941018). Plays a role in phosphatidylinositol-4-phophate (PI4P) turnover at the neuronal membrane. Localizes at the neurons plasma membrane-endoplasmic reticulum contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) from the endoplasmic reticulum for phosphatidylinositol-4-phosphate (1,2- diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) from the plasma membrane (By similarity). Binds via its PH domain PI4P, phosphatidylinositol-4,5-diphosphate, phosphatidylinositol-3,4,5- triphosphate, and phosphatidic acid (By similarity). Weakly binds 25- hydroxycholesterol (PubMed:17428193). {ECO:0000250|UniProtKB:Q8BXR9, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:26941018}. This is the function of OSBPL6 (oxysterol binding protein like 6, Ensembl gene identifier ENSG00000079156).