The function of ENSG00000092295 (TGM1, transglutaminase 1) is as follows. Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins (PubMed:7629111, PubMed:8824274, PubMed:26220141, PubMed:20663883). Responsible for cross-linking epidermal proteins during formation of the stratum corneum (PubMed:26220141). Involved in cell proliferation (PubMed:26220141). {ECO:0000269|PubMed:20663883, ECO:0000269|PubMed:26220141, ECO:0000269|PubMed:7629111, ECO:0000269|PubMed:8824274}.