The function of Ensembl gene identifier ENSG00000099949 (LZTR1, leucine zipper like post translational regulator 1) is as follows. Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras GTPases (M-Ras/MRAS, K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS) and Ras- like protein RIT1 (PubMed:30442762, PubMed:30442766, PubMed:30481304, PubMed:40934300). Acts as a negative regulator of RAS-MAPK signaling by controlling Ras levels and decreasing Ras association with membranes (PubMed:30442762, PubMed:30442766, PubMed:30481304, PubMed:40934300). {ECO:0000269|PubMed:30442762, ECO:0000269|PubMed:30442766, ECO:0000269|PubMed:30481304, ECO:0000269|PubMed:40934300}.