The function of APOL1 (apolipoprotein L1, ENSG00000100342) is as follows. May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. A component of trypanosome lytic factor of human serum; plays a crucial role in killing Trypanosoma brucei by forming pores in parasite lysosomal membranes and sensitizing T.brucei to oxidation-stimulated osmotic lysis (PubMed:12621437, PubMed:16020735, PubMed:19997494, PubMed:26645690, PubMed:7723792). {ECO:0000269|PubMed:12621437, ECO:0000269|PubMed:16020735, ECO:0000269|PubMed:19997494, ECO:0000269|PubMed:26645690, ECO:0000269|PubMed:7723792}.