The function of Ensembl gene identifier ENSG00000102908 (NFAT5, nuclear factor of activated T cells 5) is as follows. Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes (PubMed:10377394, PubMed:11485737, PubMed:41652173). Binds the DNA consensus sequence 5'- [ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394, PubMed:11485737). Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA:RNA hybrid and the associated non- template single-stranded DNA (PubMed:34049076). {ECO:0000269|PubMed:10051678, ECO:0000269|PubMed:10377394, ECO:0000269|PubMed:11485737, ECO:0000269|PubMed:22266867, ECO:0000269|PubMed:34049076, ECO:0000269|PubMed:41652173}.