The function of Ensembl gene identifier ENSG00000104885 (DOT1L, DOT1 like histone lysine methyltransferase) is as follows. Histone methyltransferase that methylates 'Lys-79' of histone H3 (PubMed:12123582, PubMed:38503750, PubMed:38129415). Histones in nucleosomes are preferred as substrate compared to free histones (PubMed:12123582, PubMed:38503750). Binds to DNA (PubMed:12628190, PubMed:38503750). Together with MLLT3/AF9, is involved in SCNN1A transcriptional repression following H3K79 hypermethylation at the promoter (By similarity). {ECO:0000250|UniProtKB:Q6XZL8, ECO:0000269|PubMed:12123582, ECO:0000269|PubMed:12628190, ECO:0000269|PubMed:38129415, ECO:0000269|PubMed:38503750}.