Catalyzes the hydrolysis of epoxide-containing fatty acids. Active in vitro against epoxyeicosatrienoic acids (EETs) including 8,9- EET, 9,10-EET, 11,12-EET and 14,15-EET and leukotoxin. . This is the function of EPHX3 (epoxide hydrolase 3, Ensembl gene identifier ENSG00000105131).