The function of Ensembl gene identifier ENSG00000105135 (HACL2, 2-hydroxyacyl-CoA lyase 2) is as follows. Endoplasmic reticulum 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the phytosphingosine degradation pathway. .