The function of PDCD5 (programmed cell death 5, Ensembl gene identifier ENSG00000105185) is as follows. In response to DNA damage, associates with TP53/p53 to prevent MDM2-mediated degradation of TP53 and promote TP53-mediated signaling (PubMed:19616514, PubMed:22914926, PubMed:28051100). Also protects KAT5/TIP60 from degradation, which further promotes TP53/p53- mediated signaling (PubMed:19308289). {ECO:0000269|PubMed:19308289, ECO:0000269|PubMed:19616514, ECO:0000269|PubMed:22914926, ECO:0000269|PubMed:28051100}.