May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. . The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis. . This is the function of APLP1 (amyloid beta precursor like protein 1, ENSG00000105290).