The function of ICAM5 (intercellular adhesion molecule 5, ENSG00000105376) is as follows. Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring neuron cell-leukocyte adhesion (PubMed:8995416). Creates homophilic cell adhesion promoting dendritogenesis and arborization of hippocampal neurons (PubMed:10893271). {ECO:0000269|PubMed:10893271, ECO:0000269|PubMed:8995416}.