The function of Ensembl gene identifier ENSG00000105409 (ATP1A3, ATPase Na+/K+ transporting subunit alpha 3) is as follows. Neuron-specific alpha catalytic component of the Na(+)/K(+)- transporting ATPase, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane (PubMed:36075933). Transports 3 Na(+) ions out of the cell and 2 K(+) ions into the cell for each ATP hydrolyze against their electrochemical gradients to maintain ion concentration gradients across the membranes (By similarity). In the brain, ATP1A3 is critical for neuronal cell signaling and for maintenance of electrochemical stability, enabling cell excitation and action potential propagation (PubMed:33880529, PubMed:36075933). {ECO:0000250|UniProtKB:P05023, ECO:0000269|PubMed:33880529, ECO:0000269|PubMed:36075933}.