The function of GRWD1 (glutamate rich WD repeat containing 1, Ensembl gene identifier ENSG00000105447) is as follows. Histone binding protein that regulates chromatin dynamics and loading of minichromosome maintenance (MCM) complex at replication origins, possibly by promoting chromatin openness (PubMed:25990725). Plays a role in ribosomal biogenesis (PubMed:15885502). .