The function of Ensembl gene identifier ENSG00000106123 (EPHB6, EPH receptor B6) is as follows. Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2 (PubMed:12517763, PubMed:15955811). Can recruit SH2 domain-containing signaling adapters following phosphorylation by EPHB4 (PubMed:34431498). {ECO:0000269|PubMed:12517763, ECO:0000269|PubMed:15955811, ECO:0000269|PubMed:34431498}.