The function of ENSG00000106144 (CASP2, caspase 2) is as follows. Is a regulator of the cascade of caspases responsible for apoptosis execution (PubMed:11156409, PubMed:15073321, PubMed:8087842). Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321). {ECO:0000269|PubMed:11156409, ECO:0000269|PubMed:15073321, ECO:0000269|PubMed:8087842}. [Isoform 1]: Acts as a positive regulator of apoptosis. . [Isoform 2]: Acts as a negative regulator of apoptosis. . [Isoform 3]: May function as an endogenous apoptosis inhibitor that antagonizes caspase activation and cell death. .