The function of NRF1 (nuclear respiratory factor 1, Ensembl gene identifier ENSG00000106459) is as follows. Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.