Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment (PubMed:9211930, PubMed:15215310). Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5 (By similarity). Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5 (PubMed:15215310). Has a S-palmitoyl transferase activity (PubMed:15479160, PubMed:15044687). Essential for the structural and functional organization of the Golgi apparatus (PubMed:32128853). {ECO:0000250|UniProtKB:Q5EGY4, ECO:0000269|PubMed:15044687, ECO:0000269|PubMed:15215310, ECO:0000269|PubMed:15479160, ECO:0000269|PubMed:32128853, ECO:0000269|PubMed:9211930}. This is the function of YKT6 (YKT6 vesicular SNARE protein, ENSG00000106636).