Core component of the HUSH2 complex, a multiprotein complex that mediates epigenetic repression of interferon-stimulated genes (PubMed:39013473, PubMed:39489739). TASOR2 is recruited to interferon- stimulated genes by IRF2, leading to transcriptional silencing by the HUSH2 complex via a H3K9me3-independent mechanism (PubMed:39013473). Within the HUSH2 complex, TASOR2 acts as the central scaffold, which recruits MPHOSPH8 and PPHLN1 (PubMed:39013473). . This is the function of Ensembl gene identifier ENSG00000108021 (TASOR2, transcription activation suppressor family member 2).