The function of Ensembl gene identifier ENSG00000108187 (PBLD, phenazine biosynthesis like protein domain containing) is as follows. Functions as a positive regulator of the antiviral immune response by modulating innate immunity and viral replication by enhancing type I interferon (IFN-I) response (PubMed:39362857, PubMed:39589880, PubMed:39779683). PBLD enhances IFN-I signaling via multiple pathways (PubMed:39362857, PubMed:39589880, PubMed:39779683). Promotes IRF3-mediated IFN-I production and apoptosis, thereby inhibiting viral replication (PubMed:39362857). Upregulates IFN-I response by activating the NF-kappaB signaling pathway, potentially through inhibition of TRIM21-mediated degradation of phosphorylated IKKbeta, thereby sustaining NF-kappaB activation to counteract viral infection (PubMed:39779683). Additionally, promotes the p53-USP4-MAVS signaling axis by stabilizing MAVS through USP4-mediated deubiquitination, thereby enhancing the IFN-I response against RNA virus infection (PubMed:39589880). Acts as a tumor suppressor, regulating development of various cancers (PubMed:23687415, PubMed:26594798). {ECO:0000269|PubMed:23687415, ECO:0000269|PubMed:26594798, ECO:0000269|PubMed:39362857, ECO:0000269|PubMed:39589880, ECO:0000269|PubMed:39779683}.