The function of Ensembl gene identifier ENSG00000109181 (UGT2B10, UDP glucuronosyltransferase family 2 member B10) is as follows. UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:17576790, PubMed:18238858, PubMed:28803208). Specialized in N-glucuronidation of tertiary amine-containing drugs and xenobiotics (PubMed:20133892, PubMed:28803208). Catalyzes N-glucuronidation of tobacco alkaloids, tobacco-specific nitrosamines, tricyclic antidepressants and compounds containing imidazole groups (PubMed:17576790, PubMed:18238858, PubMed:18300939, PubMed:20133892, PubMed:28803208). Major enzyme responsible for detoxification of tobacco-specific nitrosamines (PubMed:18238858, PubMed:18300939). Shows strong preference for tertiary aliphatic and cyclic amines over secondary or primary amines (PubMed:20133892, PubMed:28803208). Does not glucuronidate steroids, hyodeoxycholic acid, or phenolic xenobiotics (PubMed:8333863). {ECO:0000269|PubMed:17576790, ECO:0000269|PubMed:18238858, ECO:0000269|PubMed:18300939, ECO:0000269|PubMed:20133892, ECO:0000269|PubMed:28803208, ECO:0000269|PubMed:8333863}.