Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (PubMed:21926987, PubMed:27120157, PubMed:27509861). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:29033132). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys- 48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (PubMed:27120157, PubMed:27509861). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (PubMed:21926987, PubMed:27509861). Also required for degradation of CDC20 (PubMed:21926987). {ECO:0000269|PubMed:21926987, ECO:0000269|PubMed:27120157, ECO:0000269|PubMed:27509861, ECO:0000269|PubMed:29033132}. This is the function of Ensembl gene identifier ENSG00000110200 (ANAPC15, anaphase promoting complex subunit 15).