The function of Ensembl gene identifier ENSG00000110852 (CLEC2B, C-type lectin domain family 2 member B) is as follows. Membrane-bound protein expressed on myeloid cells which acts as a ligand to stimulate the activating receptor NKp80/KLRF1, expressed on the surface of natural killer (NK) cells. In turn, stimulates NK- cell cytotoxicity and cytokine production leading to the cytolysis of malignant CLEC2B-expressing myeloid cells. {ECO:0000269|PubMed:17057721, ECO:0000269|PubMed:18230726, ECO:0000269|PubMed:23929856}.