Mono-ADP-ribosyltransferase that mediates mono-ADP- ribosylation of target proteins (PubMed:25043379, PubMed:25673562). Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). Inhibits the type I interferon activated signaling pathway (PubMed:30988430). Mechanistically, mono- ADP-ribosylates beta-TrCP/BTRC to promote IFNAR1 ubiquitination and protect BTRC from ubiquitin-proteasome degradation. Additionally, acts as an antiviral factor by cooperating with PARP12 to suppress Zika virus replication, independent of IFNAR1 regulation or intrinsic PARP enzymatic activity (PubMed:34187568). Instead, facilitates the degradation of viral NS1 and NS3 proteins, potentially disrupting viral replication (PubMed:34187568). {ECO:0000250|UniProtKB:Q8CFF0, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:25673562, ECO:0000269|PubMed:30988430, ECO:0000269|PubMed:34187568}. This is the function of ENSG00000111224 (PARP11, poly(ADP-ribose) polymerase family member 11).