The function of RIC8B (RIC8 guanine nucleotide exchange factor B, Ensembl gene identifier ENSG00000111785) is as follows. Chaperone that specifically binds and folds nascent G(s) G- alpha proteins (GNAS and GNAL) prior to G protein heterotrimer formation, promoting their association with the plasma membrane (By similarity). Also acts as a guanine nucleotide exchange factor (GEF) for G(s) proteins by stimulating exchange of bound GDP for free GTP (By similarity). Acts as an important component for odorant signal transduction by mediating GNAL (G(olf)-alpha) folding, thereby promoting-dependent cAMP accumulation in olfactory sensory neurons (By similarity). .