The function of ERBIN (erbb2 interacting protein, ENSG00000112851) is as follows. Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). Acts as a mediator of keratinocyte differentiation by sequestering SHOC2 away from ERK- activating RAS complexes (PubMed:23524970). {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:16203728, ECO:0000269|PubMed:23524970}.