The function of GHR (growth hormone receptor, Ensembl gene identifier ENSG00000112964) is as follows. Receptor for pituitary gland growth hormone (GH1) involved in regulating postnatal body growth (PubMed:1549776, PubMed:2825030, PubMed:8943276). On ligand binding, couples to the JAK2/STAT5 pathway (PubMed:1549776, PubMed:15690087, PubMed:2825030, PubMed:8943276). {ECO:0000269|PubMed:1549776, ECO:0000269|PubMed:15690087, ECO:0000269|PubMed:2825030, ECO:0000269|PubMed:8943276}. [Growth hormone-binding protein]: The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. . [Isoform 2]: Up-regulates the production of the soluble Growth hormone-binding protein form (GHBP) and acts as a negative inhibitor of growth hormone signaling. {ECO:0000269|PubMed:8855247, ECO:0000269|PubMed:9360546}.