The function of ENSG00000112972 (HMGCS1, 3-hydroxy-3-methylglutaryl-CoA synthase 1) is as follows. Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis. .