The function of ENSG00000115129 (TP53I3, tumor protein p53 inducible protein 3) is as follows. NADPH:quinone reductase which expression is induced by p53/TP53 and is involved in both the DNA damage response through homologous recombination repair, and p53-mediated apoptosis (PubMed:19349281, PubMed:33782397). Catalyzes the NADPH-dependent reduction of quinones, exhibiting a low enzymatic activity with beta- naphthoquinones and a strong preference for the ortho-quinone isomer (1,2-beta-naphthoquinone) over the para isomer (1,4-beta- naphthoquinone). Also displays a low reductase activity for non-quinone compounds such as diamine and 2,6-dichloroindophenol (in vitro) (PubMed:19349281). The reduction of 1,2-naphthoquinone concurrently generates reactive oxygen species (ROS), which may trigger apoptosis downstream of p53/TP53 (PubMed:19349281). {ECO:0000269|PubMed:19349281, ECO:0000269|PubMed:33782397}.