The function of Ensembl gene identifier ENSG00000117543 (DPH5, diphthamide biosynthesis 5) is as follows. S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. .