G protein-coupled receptor for CRH and UCN stress hormones, which plays a central role in whole body adaptation to stress (PubMed:18292205, PubMed:18801728, PubMed:20966082, PubMed:23576434, PubMed:23863939, PubMed:24290358, PubMed:32004469, PubMed:32004470). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and downstream effectors, such as adenylate cyclase (PubMed:18292205, PubMed:32004469, PubMed:32004470). CRHR1 is mainly coupled to G(s) G protein (GNAS), mediating activation of adenylate cyclase activity and production of cAMP (PubMed:18292205, PubMed:32004469, PubMed:32004470). In some conditions, can also couple to G(q) G protein (GNAQ) and mediate production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers (PubMed:14657255). CRHR1-dependent signaling is a primary mediator of the neuroendocrine, autonomic (fight-or-flight) and behavioral responses to stress, acting as a key regulator of adaptation by activating the hypothalamus-pituitary-adrenal axis, leading to corticotropin hormone (ACTH) production (By similarity). Mediates both anxiogenic and anxiolytic response to stress in glutamatergic and dopaminergic neurons, respectively (By similarity). CRHR1 also plays a critical role in addiction by mediating the brain's stress response, particularly during withdrawal and relapse: it drives the transition to compulsive drug seeking by increasing anxiety and negative emotional states (By similarity). {ECO:0000250|UniProtKB:P35347, ECO:0000269|PubMed:14657255, ECO:0000269|PubMed:18292205, ECO:0000269|PubMed:18801728, ECO:0000269|PubMed:20966082, ECO:0000269|PubMed:23576434, ECO:0000269|PubMed:23863939, ECO:0000269|PubMed:24290358, ECO:0000269|PubMed:32004469, ECO:0000269|PubMed:32004470}. [Isoform CRF-R3]: Does not bind to CRH with high affinity. . This is the function of CRHR1 (corticotropin releasing hormone receptor 1, ENSG00000120088).