The function of ENSG00000121644 (DESI2, desumoylating isopeptidase 2) is as follows. Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'- linked polyubiquitin chains. Deubiquitinates 'Lys-48'-linked polyubiquitination of RPS7 leading to its stabilization (PubMed:28483520). Exhibits palmitoyl protein thioesterase (S- depalmitoylation) activity towards synthetic substrates 4- methylumbelliferyl-6-S-palmitoyl-beta-D-glucopyranoside and S- depalmitoylation probe 5 (DPP-5) (PubMed:35427157). .