[Plasmin]: Protease which primary function is to degrade fibrin, the main component of blood clots (PubMed:6094526, PubMed:6919539). Also cleaves other components of blood clots like thrombospondin-1/THBS1 and von Willebrand factor/VWF (PubMed:24449821, PubMed:7679575). Can also directly and/or through the activation of other proteases degrade the various components of the extracellular matrix including collagen, fibronectin and laminin (PubMed:14699093, PubMed:28849762, PubMed:9171346). Thereby, regulates a variety of biological processes including embryonic development, tissue remodeling, and inflammation (PubMed:9171346). In ovulation, weakens the walls of the Graafian follicle (By similarity). In vitro, it is also able to cleave several complement zymogens, such as C1, C4 and C5 (PubMed:6447255). {ECO:0000250|UniProtKB:Q01177, ECO:0000269|PubMed:14699093, ECO:0000269|PubMed:24449821, ECO:0000269|PubMed:28849762, ECO:0000269|PubMed:6094526, ECO:0000269|PubMed:6447255, ECO:0000269|PubMed:6919539, ECO:0000269|PubMed:7679575, ECO:0000269|PubMed:9171346}. [Angiostatin]: Has an antiangiogenic activity and inhibits neovascularization (PubMed:10077593, PubMed:7525077, PubMed:9102221). Could act through the inhibition of the ATP synthase subunit ATP5F1A (PubMed:10077593). {ECO:0000269|PubMed:10077593, ECO:0000269|PubMed:7525077, ECO:0000269|PubMed:9102221}. (Microbial infection) Binds to OspC on the surface of B.burgdorferi cells, possibly conferring an extracellular protease activity on the bacteria that allows it to traverse host tissue. . (Microbial infection) Interacts with dengue virus type 2 particles (PubMed:31726374). Enhances dengue virus type 2 infection in Aedes aegypti mosquito midgut by increasing midgut internalization, resulting in higher infection rates and viral dissemination in mosquitoes (PubMed:31726374). . This is the function of Ensembl gene identifier ENSG00000122194 (PLG, plasminogen).