The function of GPR83 (G protein-coupled receptor 83, ENSG00000123901) is as follows. G protein-coupled peptide receptor (PubMed:27117253, PubMed:37689599). Several peptides, PEN, derived from the proSAAS precursor (encoded by PCSK1N), the procholecystokinin-derived peptide proCCK56-63, and the related proteins FAM237A and FAM237B have been reported to activate GPR83 through GNAI1/G(i) and GNAS/G(s)-mediated signaling pathways (PubMed:27117253, PubMed:32713278, PubMed:36853120, PubMed:37689599). However, due to conflicting evidence about the ability of these peptides to bind to and activate the GPR83, the endogenous ligand of GPR83 still remains uncertain (PubMed:36853120, PubMed:37894796). Plays a role in food intake and body weight regulation. May contribute to the regulation of anxiety-related behaviors (By similarity). {ECO:0000250|UniProtKB:P30731, ECO:0000269|PubMed:27117253, ECO:0000269|PubMed:32713278, ECO:0000269|PubMed:36853120, ECO:0000269|PubMed:37689599, ECO:0000269|PubMed:37894796}.