The function of Ensembl gene identifier ENSG00000125734 (GPR108, G protein-coupled receptor 108) is as follows. May play a role in intracellular immune modulation by activating NF-kappaB response and attenuating Toll-like-receptor response. . (Microbial infection) Plays an essential function in adeno- associated virus (AAV) transduction across multiple serotypes except AAV5. May play a critical role in mediating the endosomal virus escape or in the AAV virions trafficking from endosomes to the nucleus. .