The function of NKX2-2 (NK2 homeobox 2, ENSG00000125820) is as follows. Transcriptional activator involved in the development of insulin-producing beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity). .