G protein-coupled receptor that plays key roles in the renin- angiotensin system (RAS) specifically in the protective, counter- regulatory arm of the RAS (PubMed:25967876). Receptor mainly stimulated by angiotensin 1-7, which is a bioactive metabolite of the angiotensin produced by ACE2 (PubMed:17984366). Activation promotes nitric oxide via PI3K/Akt-eNOS pathway (PubMed:17984366). Modulates also the MAPK, ERK1/2, and NF-kappa-B signaling (PubMed:25967876). Positive regulation of AGTR1 levels occurs through activation of the G proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade (PubMed:15809376, PubMed:16611642). The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1 (PubMed:15809376, PubMed:16611642). Acts as functional receptor for CXCL17 and induces chemotactic movement (PubMed:41167449). {ECO:0000250|UniProtKB:P30554, ECO:0000269|PubMed:15809376, ECO:0000269|PubMed:16611642, ECO:0000269|PubMed:17984366, ECO:0000269|PubMed:41167449}. This is the function of Ensembl gene identifier ENSG00000130368 (MAS1, MAS1 proto-oncogene, G protein-coupled receptor).