The function of ENSG00000130589 (HELZ2, helicase with zinc finger 2) is as follows. Multifunctional nuclear protein involved in RNA surveillance, nuclear receptor-mediated transcriptional regulation, and the restriction of mobile genetic elements as part of the innate immune response (PubMed:37602378). Degrades highly structured RNAs through its concerted ATP-dependent RNA helicase and 3' to 5' exoribonuclease activities (PubMed:37602378). Shows a strong preference for pyrimidine over purine residues for its nuclease activity (PubMed:37602378). Acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA (PubMed:16239304, PubMed:23525231). In addition, regulates lipid metabolism independently of PPARs by controlling the stability of Apob mRNA, which encodes a protein essential for lipoprotein assembly and secretion (PubMed:41446920). Also contributes to adipocyte differentiation through interactions with the splicing factor proline- and glutamine- rich protein SFPQ and THRAP3 (PubMed:34052659, PubMed:23525231). {ECO:0000269|PubMed:16239304, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:34052659, ECO:0000269|PubMed:37602378, ECO:0000269|PubMed:41446920}.