[Peptide YY]: Ligand for neuropeptide Y receptor type 1 (NPY1R) and neuropeptide Y receptor type 2 (NPY2R) (PubMed:1317848, PubMed:7592910, PubMed:36525977). Also binds NPY5R (By similarity). Receptor binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production (PubMed:1317848, PubMed:7592910). Receptor activation by PYY also leads to an increase of intracellular Ca(2+) levels (PubMed:1317848, PubMed:36525977, PubMed:7592910). This gut peptide inhibits exocrine pancreatic secretion (By similarity). Involved in the regulation of colonic antisecretory tone, and colonic contractility (By similarity). {ECO:0000250|UniProtKB:P68005, ECO:0000250|UniProtKB:Q9EPS2, ECO:0000269|PubMed:1317848, ECO:0000269|PubMed:36525977, ECO:0000269|PubMed:7592910}. [Peptide YY(3-36)]: Is a NPY2R agonist involved in the down- regulation of appetite and food intake, probably acting on receptors located on proopiomelanocortin(POMC)-releasing and neuropeptide Y(NPY)- releasing neurons in the arcuate nucleus of hypothalamus (PubMed:12167864). In NPY-releasing neurons, NPY2R activation by PYY(3- 36) leads to membrane hyperpolarization and reduced release of the orexigenic neuropeptide NPY (By similarity). . This is the function of PYY (peptide YY, Ensembl gene identifier ENSG00000131096).