The function of Ensembl gene identifier ENSG00000131100 (ATP6V1E1, ATPase H+ transporting V1 subunit E1) is as follows. Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32001091, PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (PubMed:32001091). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (PubMed:22053050, PubMed:39695235). {ECO:0000269|PubMed:22053050, ECO:0000269|PubMed:33065002, ECO:0000269|PubMed:39695235, ECO:0000303|PubMed:32001091}.