The function of Ensembl gene identifier ENSG00000131263 (RLIM, ring finger protein, LIM domain interacting) is as follows. E3 ubiquitin-protein ligase that acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex (PubMed:29742418, PubMed:33953269). Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42/REX1 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals. E3 ubiquitin-protein ligase is required for proper regulation of neural cell differentiation from embryonic stem cells (By similarity). {ECO:0000250|UniProtKB:Q9WTV7, ECO:0000269|PubMed:19164295, ECO:0000269|PubMed:19945382, ECO:0000269|PubMed:29728705, ECO:0000269|PubMed:29742418, ECO:0000269|PubMed:33953269}.