The function of PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1, ENSG00000131828) is as follows. Together with PDHB forms the heterotetrameric E1 subunit of the pyruvate dehydrogenase (PDH) complex (PubMed:17474719, PubMed:19081061). The PDH complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle (PubMed:19081061, PubMed:7782287). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3) (Probable). The E1 subunit catalyzes both the thiamine pyrophosphate (TPP)-dependent decarboxylation of pyruvate and the reductive acetylation of a lipoyl group covalently linked to the lipoyl-bearing domains of E2 (PubMed:17474719, PubMed:19081061, PubMed:7782287). {ECO:0000269|PubMed:17474719, ECO:0000269|PubMed:19081061, ECO:0000269|PubMed:7782287, ECO:0000305|PubMed:17474719, ECO:0000305|PubMed:19081061, ECO:0000305|PubMed:7782287}.