The function of GPR12 (G protein-coupled receptor 12, ENSG00000132975) is as follows. Brain-specific G protein-coupled receptor involved in regulating diverse physiological processes including neurite outgrowth, meiotic arrest, and lipid and carbohydrate metabolism (By similarity). Functions as a receptor with constitutive G(s)-mediated signaling activity that stimulates cyclic AMP (cAMP) production (PubMed:36593162). Also engages the G(i)/G(o) pathway, which counteracts the cAMP increase driven by G(s) activation (PubMed:12220620). Additionally, two lipids sphingosylphosphorylcholine (SPC) and sphingosine-1-phosphate (S1P) may act as endogenous ligand and activate GPR12 (PubMed:12220620). {ECO:0000250|UniProtKB:P35412, ECO:0000269|PubMed:12220620, ECO:0000269|PubMed:36593162}.