The function of TRPC4 (transient receptor potential cation channel subfamily C member 4, Ensembl gene identifier ENSG00000133107) is as follows. Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:11042129, PubMed:11713258, PubMed:16144838, PubMed:39478185). Acts as a cell-cell contact-dependent endothelial calcium entry channel (PubMed:19996314). Forms a homomeric ion channel or a heteromeric ion channel with TRPC1; the heteromeric ion channel has reduced calcium permeability compared to the homomeric channel (PubMed:39478185). Also permeable to monovalent ions including sodium, lithium and cesium ions (PubMed:39478185). {ECO:0000250|UniProtKB:Q9QUQ5, ECO:0000269|PubMed:11042129, ECO:0000269|PubMed:11713258, ECO:0000269|PubMed:16144838, ECO:0000269|PubMed:19996314, ECO:0000269|PubMed:39478185}. [Isoform Beta]: Forms a receptor-activated non-selective calcium permeant cation channel. .