The function of KCTD1 (potassium channel tetramerization domain containing 1, ENSG00000134504) is as follows. Is a regulator of different signaling pathways. Up-regulates ADCY5 thereby enhancing cAMP signaling, and is involved in the negative regulation of Wnt canonical, Hh and Notch signaling (PubMed:41086914). Is a repressor of transcriptional activation mediated by AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent (PubMed:18358072, PubMed:19115315, PubMed:33000225). {ECO:0000269|PubMed:18358072, ECO:0000269|PubMed:19115315, ECO:0000269|PubMed:33000225, ECO:0000269|PubMed:41086914}.