The function of ENSG00000135069 (PSAT1, phosphoserine aminotransferase 1) is as follows. Involved in L-serine biosynthesis via the phosphorylated pathway, a three-step pathway converting the glycolytic intermediate 3- phospho-D-glycerate into L-serine (PubMed:36851825, PubMed:37627284). Catalyzes the second step, that is the pyridoxal 5'-phosphate-dependent transamination of 3-phosphohydroxypyruvate and L-glutamate to O- phosphoserine (OPS) and alpha-ketoglutarate (PubMed:36851825, PubMed:37627284). Acts as an inhibitor of ferroptosis in response to interferon-gamma (IFNG) by promoting GPX4 stability: following phosphorylation by CAMK2A, PSAT1 interacts with GPX4 and provides 2- oxoglutarate to EGLN3, leading to GPX4 hydroxylation and stability (PubMed:40281343). {ECO:0000269|PubMed:12633500, ECO:0000269|PubMed:36851825, ECO:0000269|PubMed:37627284, ECO:0000269|PubMed:40281343}.