Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). . This is the function of Ensembl gene identifier ENSG00000135074 (ADAM19, ADAM metallopeptidase domain 19).